| Autor: |
Fatimazahra, Moukhfi, Jamila, Chninigue, Achraf, Abdou, Maaghloud, Fatima Ezzahra, Nour-eddine, Chadli, Mohamed, Dakir |
| Zdroj: |
Chemistry Africa; May 2024, Vol. 7 Issue: 4 p1865-1876, 12p |
| Abstrakt: |
This research aimed to analyze the chemical composition of Rosmarinus officinalis L. essential oil collected from Morocco using GC/MS. The primary compound of EO was further isolated and purified to evaluate its antibacterial activity and antioxidant effects. The results showed that eucalyptol was the major compound of the EO, representing 34.06%. The EO exhibited an IC50of 3.23 mg/ml through the DPPH assay, whereas eucalyptol displayed no antiradical activity. In comparison, the molybdate assay revealed an EC50of 0.23 mg/ml and 0.58 mg/ml, respectively. EO and eucalyptol exhibited antibacterial activity against all tested strains (E. coliand Salmonella). The MIC ranged from 0.35 to 11.37 mg/ml for eucalyptol and 5.68 to 45.50 mg/ml for EO. Furthermore, the molecular docking scores of eucalyptol and the amino acids of various proteins of E. coliand Salmonellawere investigated, and the results demonstrated strong interactions between eucalyptol and the proteins of the bacteria. |
| Databáze: |
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