| Autor: |
Tay, Chia Chay, Mohamad-Nasir, Najihah, Hashim, Saiyidah Nafisah, Lokman, Nurul Fariha, Wong, Kok Kee |
| Zdroj: |
Proceedings of the National Academy of Sciences, India Section B; April 2024, Vol. 94 Issue: 2 p383-388, 6p |
| Abstrakt: |
This research reports on the efficiency of Rhodococcus zopfiiand Leifsonia shinshuensisto degrade approximately 99.98 ± 0.20% carbamazepine (CBZ) within 5 days. The degradation of CBZ was strongly correlated (R2≥ 0.9) to bacterial growth in L. shinshuensis, but only moderate (R2≈ 0.6) in R. zopfii. Both oxygen oxidoreductase and aldehyde oxidase concentrations were positively and strongly correlated (R2≈ 0.9) to the degradation rate of CBZ in both cultures. However, when it comes to bacterial growth (CFU mL−1/h), only the culture of L. shinshuensisshowed a strong positive correlation (R2≈ 0.9) to both enzyme concentrations, whereas the culture of R. zopfiionly shows a moderate correlation (R2≈ 0.7). The degradation of CBZ by R. zopfiidid not directly translate into higher bacterial growth. This demonstrated the possibility of different CBZ degradation strategies was being adopted by these two different bacteria. Hence, this piece of information is important to elucidate the mechanisms of carbamazepine degradation and sustainable treatment. |
| Databáze: |
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