| Autor: |
Munukka, Eveliina, Rintala, Anniina, Toivonen, Raine, Nylund, Matts, Yang, Baoru, Takanen, Anna, Hänninen, Arno, Vuopio, Jaana, Huovinen, Pentti, Jalkanen, Sirpa, Pekkala, Satu |
| Zdroj: |
The ISME Journal; July 2017, Vol. 11 Issue: 7 p1667-1679, 13p |
| Abstrakt: |
Faecalibacterium prausnitziiis considered as one of the most important bacterial indicators of a healthy gut. We studied the effects of oral F. prausnitziitreatment on high-fat fed mice. Compared to the high-fat control mice, F. prausnitzii-treated mice had lower hepatic fat content, aspartate aminotransferase and alanine aminotransferase, and increased fatty acid oxidation and adiponectin signaling in liver. Hepatic lipidomic analyses revealed decreases in several species of triacylglycerols, phospholipids and cholesteryl esters. Adiponectin expression was increased in the visceral adipose tissue, and the subcutaneous and visceral adipose tissues were more insulin sensitive and less inflamed in F. prausnitzii-treated mice. Further, F. prausnitziitreatment increased muscle mass that may be linked to enhanced mitochondrial respiration, modified gut microbiota composition and improved intestinal integrity. Our findings show that F. prausnitziitreatment improves hepatic health, and decreases adipose tissue inflammation in mice and warrant the need for further studies to discover its therapeutic potential. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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