A multicentred phase III comparative study of two hormonal contraceptive preparations given once-a-month by intramuscular injection: I. Contraceptive efficacy and side effects

Autor: Said, S., Sadek, W., Knoieif, A., Koetsawang, Suporn, Kiriwat, Orawan, Piboonmanee, Surat, Rivera, R., Alvarado, G., Juarez, M.A., Aguliar, S., Santiso, R., Contreras, C.F., Galichi, L.F., Guliora, M., Alzugaray, M.G., Hernandez, M.L., Gallardo, J.R., Affandi, B., Santoso, S.S.I., Jamil, R.S., Kazi, A., Kononova, E.S., Ailpov, V.I., Apeio, R., Hernardo, E.S., Benitez, I., Canto-de-Cetina, T., Cardenas, S., Polanco, L., Vera, L., Cravioto, M.-C., Hernandez, L., Fuziwara, J.L., Garza-Flores, J., Perez-Palacios, G., Oropeza, G., Mota, E., Zavaleta, E., Benagiano, G., Bastianelli, C., Diaz Infante-Ibarra, A., Castelo, C.J., Jimenez, R., Perez-Arocha, N., Lang-Prieto, J., Casas-Fernandez, J.A., Perez-Paz, H.M., Perez, M., Hernandez, A.R., Bustillo Tur, C., Kovacs, L., Koroszar, S., Bassol, S., Trujilio, A.M., Guzman-Serani, R., Israel, E., Hall, P.E., d’Arcangues, C., Busca, B., Macnin, D., Pinol, A., Schlagenhaft, F., Hall, Peter E.
Zdroj: Contraception; January 1988, Vol. 37 Issue: 1 p1-20, 20p
Abstrakt: Two once-a-month injectable contraceptive formulations, HRP112 (depot-medroxyprogesterone acetate, 25mg and estradiol cypionate, 5mg.) and HRP102 (norethisterone enantate, 50 mg and estradiol valerate, 5 mg,) were compared in two groups of women witn regard to effectiveness, reported complaints and reasons for discontinuation. A total of 2328 women were recruited into a seventeen-centre, randomized clinical trial. Follow-up was for a period of one year and resulted in a total of 10,969 women-months of experience of HRP112 and 10,608 women-months of experience with HRP102.
Databáze: Supplemental Index