| Autor: |
Mitsuya, Sho, Arai, Masahiro, Kanaoka, Kiyoe, Funamoto, Tomoya, Tsuji, Hiroyuki, Tsuruoka, Kenjiro, Matsunaga, Ninso, Nakamura, Takahiko, Tamura, Yosuke, Imanishi, Masafumi, Ikeda, Soichiro, Imagawa, Akihisa, Fujisaka, Yasuhito |
| Zdroj: |
JTO Clinical and Research Reports; 20240101, Issue: Preprints |
| Abstrakt: |
Osimertinib administration has been approved as an adjuvant treatment after complete surgical resection in patients with epidermal growth factor receptor-mutated non-small cell lung cancer. This paper presents the first report of life-threatening postoperative osimertinib-induced interstitial lung disease. An 83-year-old male patient underwent right upper lobectomy (pathological stage IIA) and osimertinib (80 mg/day) was initiated on postoperative day 75. On day 44 of osimertinib administration, chest computed tomography revealed diffuse ground-glass opacities; accordingly, osimertinib-induced interstitial lung disease was diagnosed. Steroid pulse therapy was initiated using a high-flow nasal cannula to treat dyspnea and hypoxemia, rapidly improving the respiratory status and imaging findings; moreover, the patient’s clinical course was excellent. This case report demonstrates that the postoperative occurrence of severe osimertinib-induced interstitial lung disease is a crucial factor that must be considered in patient decision-making regarding perioperative treatment. |
| Databáze: |
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