| Autor: |
Diedkova, Kateryna, Husak, Yevheniia, Simka, Wojciech, Korniienko, Viktoriia, Petrovic, Bojan, Roshchupkin, Anton, Stolarczyk, Agnieszka, Waloszczyk, Natalia, Yanko, Ilya, Jekabsons, Kaspars, Čaplovičová, Maria, Pogrebnjak, Alexander D., Zahorodna, Veronika, Gogotsi, Oleksiy, Roslyk, Iryna, Baginskiy, Ivan, Radovic, Marko, Kojic, Sanja, Riekstina, Una, Pogorielov, Maksym |
| Zdroj: |
Graphene and 2D Materials Technologies; June 2024, Vol. 9 Issue: 1-2 p59-76, 18p |
| Abstrakt: |
Effective cardiac tissue regeneration necessitates scaffolds that mimic the native extracellular matrix and possess desirable properties, such as electrical conductivity and biocompatibility. The choice of an appropriate fabrication method is paramount in achieving reproducibility, scalability, and rapid production of cardiac tissue patches. Electrospinning, a versatile and widely utilized technique, offers precise control over fiber diameter, pore size, and alignment, rendering it an ideal method for creating intricate cardiac scaffolds. In light of the limitations of existing therapies and the need for innovative approaches, this research aims to explore the development of novel patches for cardiac tissue regeneration. By investigating the integration of MXenes into electrospun polycaprolactone (PCL) membranes, we aim to harness the unique properties of MXenes to create conductive, biocompatible, and mechanically robust scaffolds that promote cell adhesion, proliferation, and functional maturation. The application of oxygen plasma treatment enhances the infiltration of MXene into the PCL electrospun membrane, significantly reducing the surface contact angle and promoting cell adhesion. Regardless of the number of MXene deposition repetitions, all variants demonstrated strong biocompatibility and supported the formation of cell symplasts after fibroblast seeding. The remarkable electrical conductivity of PCL-MXene membranes, coupled with the positive biological outcomes presented in this study, has the potential to drive significant advancements in the field of cardiac tissue engineering. This research offers fresh insights and approaches to tackle the challenges associated with myocardial repair and regeneration. |
| Databáze: |
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