| Autor: |
Kariu, Toru, Hamada, Nobushiro, Lakshmyya, Kesavalu |
| Zdroj: |
Bioscience, Biotechnology, and Biochemistry; January 2024, Vol. 88 Issue: 1 p37-43, 7p |
| Abstrakt: |
Periodontal disease is a major oral infectious disease that destroys alveolar bones and causes tooth loss. Porphyromonas gingivalisis a key pathogen that plays a crucial role in periodontitis. In our previous study on the anti-P. gingivalisactivity of flavonoid, luteolin, a major flavonoid in edible plants, inhibited the proteolytic activity of gingipains, the major virulence factor in P. gingivalis. This study demonstrated luteolin in vitroand in vivoanti-bacterial activities. Thus, luteolin inhibits planktonic growth and biofilm formation in P. gingivalis. Furthermore, oral administration of luteolin alleviated maxillary alveolar bone resorption (ABR) in murine periodontitis induced by P. gingivalisinfection. These results indicate that luteolin may be a potential therapeutic compound that targets P. gingivalisby hindering its growth, biofilm formation, and ABR in the oral cavity.Graphical AbstractAnti-periodontitis activity of luteorin in vivo |
| Databáze: |
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