| Autor: |
Azuma, Naoki, Saito, Yasuo, Nishijima, Tomohiko, Aoki, Ryo, Nishihira, Jun |
| Zdroj: |
Bioscience, Biotechnology, and Biochemistry; January 2024, Vol. 88 Issue: 1 p86-96, 11p |
| Abstrakt: |
Bifidobacterium animalissubsp. lactisGCL2505 (GCL2505) improves the intestinal microbiota and reduces human visceral fat. This randomized, double-blind, placebo-controlled, parallel-group study was conducted to examine the effects of inulin, a prebiotic dietary fiber, and GCL2505 on vascular endothelial function in healthy subjects (n= 60). The test drink contained 2.0 g/100 g inulin and 1.0 × 1010colony-forming units/100 g GCL2505 and was consumed daily for 12 weeks. Flow-mediated dilation was set as the primary endpoint. Subgroup analysis of vascular endothelial function demonstrated a significant increase in the change of flow-mediated dilation (%) from weeks 0 to 12 in the GCL2505 and inulin group (n= 24) compared with the placebo group (n= 23), while an improving trend in low-density lipoprotein cholesterol and plasminogen activator inhibitor-1 were confirmed. Our results indicated that the test drink had a positive effect on vascular endothelial function and related blood parameters.Graphical AbstractThe suggested mechanism of improving vascular endothelial function via intake of Bifidobacterium animalissubsp. lactisGCL2505 and inulin. |
| Databáze: |
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