| Autor: |
Nascimento, G. O., Marques, S. P. D., Maia, C. E. G., de Sousa, A. F., Cunha, R. L., Malta, M. R., Owen, R. W., Ferreira, M. K. A., da Silva, A. W., Rebouças, E. L., de Menezes, J. E. S. A., Marinho, M. M., Marinho, E. S., dos Santos, H. S., Saliba, A. S. M. C., Massarioli, A. P., Alencar, S. M., Sartori, A. G. O., Trevisan, M. T. S. |
| Zdroj: |
Journal of Biomolecular Structure and Dynamics; December 2023, Vol. 41 Issue: 24 p14871-14886, 16p |
| Abstrakt: |
AbstractThe present study focused on investigating the antioxidant, antiglycation activity, digestive enzymes inhibition, bioaccessibility and hypoglycemic effect of C. arabicaleaves extracts. The extracts deactivated the O2•-, ROO•, H2O2, HOCl reactive oxygen species. Coffee leaves showed strong inhibition of α-glucosidase (IC50= 40.30 μg mL−1) greater than the isolated metabolites and acarbose. There was also inhibition of pancreatic lipase (IC50= 56.43 μg mL−1) in addition to a hypoglycemic effect in zebrafish similar to acarbose and metformin. With the exception of rutin, all biocompounds were detected at all stages of in vitrodigestion. Finally, these results suggest that C. arabicaleaf extracts possess antidiabetic and anti-obesity properties that can be attributed to the main metabolites and the synergistic action between them.Communicated by Ramaswamy H. Sarma |
| Databáze: |
Supplemental Index |
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