| Abstrakt: |
An autoradiographic study of nucleic acids and protein metabolism of normal and cancerous epithelium of the cervix uteri has been undertaken. In normal epithelium, after one hour incubation in radioactive adenine, an intense incorporation of this precursor into the basal and the parabasal layers takes place. After three and five hours incubation the distribution of the radioactivity is homogenous through out the whole epithelium. The incorporation of phenylalanine is extremely high, even after five hours incubation, in the cells of the intermediary layers producing pseudo-keratin. In cancerous tissues, radioactivitydue to protein or nucleic acid metabolism is present in the whole thickness of the epithelium and in the invading cords. Radium therapy results in a considerable reduction of nucleic acid metabolism, but this is not always accompanied by a similar drop of protein activity.The method has been suggested as a test for radio-sensitivity. |
