Bone marrow suppression caused by whole body electron therapy for mycosis fungoides

Autor: Koga, Kenji, Nishikawa, Kiyoshi, Kuroki, Yasumasa, Asada, Yujiro, Sumiyoshi, Akinobu, Ogata, Katsumi, Kusuhara, Toshiyuki, Watanabe, Katsushi
Zdroj: The British Journal of Radiology; June 1985, Vol. 58 Issue: 690 p566-569, 4p
Abstrakt: Since whole body electron irradiation by a linear accelerator was first introduced by Szur et al (1962) for the treatment of generalised cutaneous mycosis fungoides, the method has been proved to be beneficial, compared with roentgen rays which cannot be used because of the inability to use multiple ports. Since then there have been a considerable number of reports on the successful results of this technique (Egawa et al, 1968; Fuks & Bagshaw, 1971; Blasko et al, 1979; Lo et al, 1979; Williams et al, 1979; Nisce et al, 1981). Grollman et al (1966) reported, however, two cases with pancytopenia and especially persistent thrombocytopenia due to the X-ray contamination. We recently encountered such a case whose bone marrow was significantly suppressed by treatment. The dose of the X-ray contamination was calculated and is discussed in detail here to draw attention to this important complication.A 62-year-old woman with a 7-year history of bronchial asthma developed pruritic skin lesions over the whole body in April 1976. She consulted her family physician who prescribed adreno-cortico-steroids. The initial improvement was maintained until November 1977, when the steroid therapy had ceased. In June 1978 numerous skin nodules of 1 to 2 cm diameter recurred over the back, right forearm and thighs. In August she was admitted to the dermatology department of Miyazaki Medical College for evaluation and treatment of her skin condition. Physical examination showed numerous skin nodules and erythematous plaques over the body and extremities.
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