| Autor: |
Yeom, Suyeon, Kim, Do Young, Kim, Seungwoo, Gontala, Arjun, Park, Jimin, Lee, Yong Ho, Kim, Hak Joong |
| Zdroj: |
Organic Letters; December 2023, Vol. 25 Issue: 50 p9008-9013, 6p |
| Abstrakt: |
This study presents a Pd(II)-catalyzed method for the β-C(sp3)–H arylation of N-Cbz- or N-Fmoc-protected N-methyl alanines, providing ready access to building blocks for N-methylated peptide synthesis. For this transformation, the native carboxylate was exploited as the directing group, attributing its success to the use of a monoprotected amino-pyridine ligand. Its synthetic utility was demonstrated by facile generation of nine analogues of the naturally occurring N-methylated cyclic peptide cycloaspeptide A. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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