Lysosomal alkalinization in nutrient restricted cancer cells activates cytoskeletal rearrangement to enhance partial epithelial to mesenchymal transition.

Autor: Hüsnügil, H. Hazal, Taşkıran, Aliye Ezgi Güleç, Güderer, Ismail, Nehri, Leman Nur, Noghreh, Ariana, Oral, Göksu, Menemenli, Nazlı Şevval, Özcan, Özün, Akyol, Aytekin, Banerjee, Sreeparna
Zdroj: Translational Oncology; 20230101, Issue: Preprints
Abstrakt: •Nutrient depletion (ND) can enable survival via the activation of partial (p)-EMT•V-ATPase inhibition with ND reduced cell adhesion, exacerbated motility and p-EMT•Membrane protrusions via microtubule reorganization led to lysosomal relocalization•Lysosomal exocytosis may increase invasive phenotype
Databáze: Supplemental Index