| Autor: |
Santisteban, Monica M., Schaeffer, Samantha, Anfray, Antoine, Faraco, Giuseppe, Brea, David, Wang, Gang, Sobanko, Melissa J., Sciortino, Rose, Racchumi, Gianfranco, Waisman, Ari, Park, Laibaik, Anrather, Josef, Iadecola, Costantino |
| Zdroj: |
Nature Neuroscience; January 2024, Vol. 27 Issue: 1 p63-77, 15p |
| Abstrakt: |
Hypertension (HTN), a disease afflicting over one billion individuals worldwide, is a leading cause of cognitive impairment, the mechanisms of which remain poorly understood. In the present study, in a mouse model of HTN, we find that the neurovascular and cognitive dysfunction depends on interleukin (IL)-17, a cytokine elevated in individuals with HTN. However, neither circulating IL-17 nor brain angiotensin signaling can account for the dysfunction. Rather, IL-17 produced by T cells in the dura mater is the mediator released in the cerebrospinal fluid and activating IL-17 receptors on border-associated macrophages (BAMs). Accordingly, depleting BAMs, deleting IL-17 receptor A in brain macrophages or suppressing meningeal T cells rescues cognitive function without attenuating blood pressure elevation, circulating IL-17 or brain angiotensin signaling. Our data unveil a critical role of meningeal T cells and macrophage IL-17 signaling in the neurovascular and cognitive dysfunction in a mouse model of HTN. |
| Databáze: |
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