Reciprocal regulation of SIRT1 and AMPK by Ginsenoside compound K impedes the conversion from plasma cells to mitigate for podocyte injury in MRL/lprmice in a B cell-specific manner

Autor: Song, Ziyu, Jin, Meng, Wang, Shenglong, Wu, Yanzuo, Huang, Qi, Xu, Wangda, Fan, Yongsheng, Tian, Fengyuan
Zdroj: Journal of Ginseng Research; March 2024, Vol. 48 Issue: 2 p190-201, 12p
Abstrakt: Deposition of immune complexes drives podocyte injury acting in the initial phase of lupus nephritis (LN), a process mediated by B cell involvement. Accordingly, targeting B cell subsets represents a potential therapeutic approach for LN. Ginsenoside compound K (CK), a bioavailable component of ginseng, possesses nephritis benefits in lupus-prone mice; however, the underlying mechanisms involving B cell subpopulations remain elusive.
Databáze: Supplemental Index