| Autor: |
Radhakrishnan, Narayanaswamy, Karthi, Sengodan, Raghuraman, Pandiyan, Ganesan, Raja, Srinivasan, Kumaraswamy, Edwin, Edward-Sam, Ganesh-Kumar, Selvaraj, Mohd Esa, Norhaizan, Senthil-Nathan, Sengottayan, Vasantha-Srinivasan, Prabhakaran, Krutmuangh, Patcharin, Alwahibi, Mona S., Elshikh, Mohamed Soliman |
| Zdroj: |
All Life; December 2023, Vol. 16 Issue: 1 |
| Abstrakt: |
In-vitrochemical characterization and mosquitocidal screening of essential oil derived from Mikania scandens(L.) Willd. (Asteraceae) (CVO-MS) against the malarial vector Anopheles gambiaewas investigated. GC-MS analysis evidenced a total of 12 bio-active compounds, and maximum at α-bisabolol (39.34%) followed by stigmasterol (13.45%) respectively. The larvicidal activity of CVO-MS against the malarial vector An. gambiaeevidenced that the mortality rate was prominent at the maximum dosage of 1000 ppm. The Median Lethal Concentration (LC50) of CVO-MS was established at 488 ± 2.45 ppm, respectively. Enzyme inhibition assay showed that the CVO-MS delivers a significant upsurge in the level of CYP450, GST, and a decline in the level of α-β carboxylesterase activity in both the third and fourth instar (p ≤ 0.0001). The gut-histological examination of CVO-MS showed that there is severe damage in the mid-gut tissues, especially epithelial layer (EL), gut-lumen (GL), and peritrophic membrane (pM). The non-target screening against the mosquito predators (A. bouvieri, D. indicus, and third instar larvae of Tx. splendens) suggests that CVO-MS showed less toxicity as compared to Pestanal® (1 ppm) respectively. The present study has paved a new insight in understanding the bioactivity of CVO-MS as a potential larvicidal agent of malarial vector and non-toxic against mosquito predators. |
| Databáze: |
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