Venetoclax–based low intensity therapy in molecular failure of NPM1-mutated AML

Autor: Jimenez-Chillon, Carlos, Othman, Jad, Taussig, David, Jimenez-Vicente, Carlos, Martinez-Roca, Alexandra, Tiong, Ing Soo, Jain, Manish, Aries, James, Cakmak, Seda, Knapper, Steven, Kristensen, Daniel Tuyet, Murthy, Vidhya, Galani, Joy Zacharoula, Kallmeyer, Charlotte, Ngu, Loretta, Veale, David, Bolam, Simon, Orfali, Nina, Parker, Anne, Manson, Cara, Parker, Jane, Erblich, Thomas, Richardson, Deborah, Mokretar, Katya, Potter, Nicola, Overgaard, Ulrik Malthe, Roug, Anne Stidsholt, Wei, Andrew H., Esteve, Jordi, Jädersten, Martin, Russell, Nigel, Dillon, Richard
Zdroj: Blood Advances; 20230101, Issue: Preprints
Abstrakt: •About 84% of the patients treated with venetoclax combinations for NPM1mut molecular failure achieved a molecular response, and 71% became MRD negative.•Venetoclax combinations are a potentially effective treatment for molecular failure, either as a bridge to transplant or as definitive therapy.
Databáze: Supplemental Index