| Autor: |
Changelian, Paul, Xu, Canxin, Mnich, Steve, Hope, Heidi, Kostecki, Kourtney, Hirsch, Jeff, Loh, Chin-Yi, Anderson, David, Blinn, James, Hockerman, Susan, Dick, Evan, Smith, Walter, Monahan, Joseph, Raoof, Tooraj, Forman, Seth, Burt, David, Barnes, Brad, Gordon, David, Walker, Neal, Sudzina, John, Tucker, Stephen, Jacobsen, Jon |
| Zdroj: |
JID Innovations; 20230101, Issue: Preprints |
| Abstrakt: |
Atopic dermatitis (AD), a chronic, pruritic skin disease, affects 10%-30% of children and up to 14% of adults in developed countries. ATI-1777, a potent and selective JAK1/3 inhibitor, was designed with multiple sites of metabolism to deliver local efficacy in the skin and limit systemic exposure. In preclinical studies, ATI-1777 selectively inhibited JAK1/3 with limited systemic exposure and without any adverse effects. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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