| Autor: |
Tanaka-Yano, Mayuri, Wang, Dahai, Chen, Diana, Isaac, Biju, Liu, Tianxin Scarlett, Sun, Liang, da Rocha, Edroaldo Lummertz, Gryder, Berkley, Orkin, Stuart H, Rowe, Robert Grant |
| Zdroj: |
Blood; November 2023, Vol. 142 Issue: 1, Number 1 Supplement 1 p2678-2678, 1p |
| Abstrakt: |
Many blood diseases are biased in their age of onset toward infancy, childhood, or mature adulthood. This occurs in concert with underlying changes in the properties of hematopoietic stem and progenitor cells (HSPCs) over the course of development, maturation, and aging that tailor the output of effector blood cells to age-specific physiology. Understanding how blood formation changes over the course of a lifetime would form a foundation upon which to investigate age-related determinants of manifestations of blood diseases. A growing body of work has shown that the heterochronic Lin28b/ let-7switch defines fetal versus adult definitive HSPC states. In previous work, we found that the Polycomb repressive complex 1 component Cbx2 is a downstream target of let-7that functions to specify the temporal maturation state of the hematopoietic system. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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