| Autor: |
Silva, Letícia Queiroz da, Huber, Stephany Cares, Martinelli, Beatriz, Saraiva, Camilla Maria de Alencar, Montalvão, Silmara Aparecida De Lima, Costa, Fernando Ferreira, De Paula, Erich Vinicius |
| Zdroj: |
Blood; November 2023, Vol. 142 Issue: 1, Number 1 Supplement 1 p2608-2608, 1p |
| Abstrakt: |
Sepsis is a life-threatening end-organ dysfunction resulting from dysregulated host responses to infection with physiopathology not fully understood. Yet, it has been long recognized that platelets and neutrophil extracellular traps collaborate to promote secondary tissue damage. Interestingly, patients with hematological malignancies and febrile neutropenia (FN) secondary to chemotherapy, with neutrophils and platelet counts frequently around zero, develop sepsis and septic shock, raising questions about which mechanisms are involved. Here, we show that extracellular vesicles (EVs) and activation of the fibrinolytic system are two potential mediators of tissue damage in sepsis among patients with very low platelets and neutrophil counts. |
| Databáze: |
Supplemental Index |
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