| Autor: |
Kuznicki, Lea, Laurance, Sandrine, Claer, Laetitia, Le Van Kim, Caroline |
| Zdroj: |
Blood; November 2023, Vol. 142 Issue: 1, Number 1 Supplement 1 p2493-2493, 1p |
| Abstrakt: |
Background :Sickle cell disease (SCD) is an inherited disorder caused by a mutation in the beta-globin gene, leading to the synthesis of sickle hemoglobin called HbS. Under deoxygenated conditions, HbS polymerizes and forms fibers that weakens red blood cells (RBC) resulting in hemolysis and vaso-occlusion. Recently, ineffective erythropoiesis in SCD has been reported, characterized by higher apoptosis levels during late erythropoiesis. Interestingly, fetal hemoglobin (HbF)-expressing erythroblasts during erythroid differentiation seem to be protected from the apoptosis. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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