| Autor: |
Serra, Marion, Hermand, Patricia, Duval, Romain, Lefevre, Carine, Merrer, Jade, Leye, Fallou, Salma, Mohammad, Aglave, Marine, Vainchenker, William, Le Van Kim, Caroline, Azouzi, Slim, Koehl, Berengere |
| Zdroj: |
Blood; November 2023, Vol. 142 Issue: 1, Number 1 Supplement 1 p1111-1111, 1p |
| Abstrakt: |
Polymorphonuclear neutrophils (PMN) have long been suspected to be involved in the pathophysiology of Sickle cell anemia (SCA) since early studies have reported a higher neutrophil count in patients at steady-state and its positive correlation with SCA severity. This high leukocyte count has long be considered as a peripheral phenomenon, driven by RBC hemolysis causing systemic inflammation and neutrophils recruitment. Nevertheless, several lines of evidence suggest that hematopoietic stem/progenitor cell (HSPC) function might be perturbed in SCA. Given that recent report showed an increased apoptosis during terminal erythroid maturation of SCA cells and that erythroid and myeloid differentiation derive from the same common myeloid progenitor (CMP), we investigated a possible enhanced myelopoiesis in SCA and its causes. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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