Diastereoselective Synthesis of the Hydroxyethylene Dipeptide Isostere of Leu–Val
| Autor: | Nishi, Takahide, Kataoka, Mitsuru, Morisawa, Yasuhiro |
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| Zdroj: | Chemistry Letters; November 1989, Vol. 18 Issue: 11 p1993-1996, 4p |
| Abstrakt: | The synthesis of hydroxyethylene dipeptide isostere of Leu–Val, a transition-state mimic, is described. The key steps of this synthetic approach are the homogeneous asymmetric hydrogenation of γ-keto esters by BINAP–Ru(II) complex, and the construction of a 2(S)-isopropyl unit. |
| Databáze: | Supplemental Index |
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