| Autor: |
Imoto, Masahiro, Kageyama, Shigeki, Kusumoto, Shoichi, Kohno, Morihiro, Matsumoto, Kensuke, Hashimoto, Shinjiro, Tohgo, Akiko, Shiba, Tetsuo |
| Zdroj: |
Bulletin of the Chemical Society of Japan; October 1986, Vol. 59 Issue: 10 p3207-3212, 6p |
| Abstrakt: |
6-Phosphate of N-acetylmuramyl-l-alanyl-d-isoglutamine and its lipophilic derivatives, i.e., 6-(octadecyl hydrogenphosphate) and 6-(2-docosyltetracosyl hydrogenphosphate) were synthesized after the structural feature of mycobacterial cell walls for the purpose to modify and possibly to enhance the immunostimulating activity of the muramyl dipeptide which is the minimum requisite for the activity. As expected, the latter more lipophilic phosphate showed a high activity in a tumor regression test. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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