Preparation and Properties of Oligocytidylates with 2'–5' Internucleotide Linkage

Autor: Sawai, Hiroaki, Ohno, Masaji
Zdroj: Bulletin of the Chemical Society of Japan; January 1985, Vol. 58 Issue: 1 p361-366, 6p
Abstrakt: Oligocytidylates upto a pentamer were prepared by lead(II) ion catalyzed polymerization of cytidine 5'-phosphorimidazolide in aqueous solution. 2'–5' internucleotide linkage was preferentially formed. The yields of the 2'–5' linked dimer, trimer, tetramer and pentamer were 17.0, 5.5, 1.9, and 0.7%, respectively. Some of their properties were studied by NMR, CD, UV, and chromatography and compared with the corresponding 3'–5' linked oligomers which were prepared enzymatically.
Databáze: Supplemental Index