| Autor: |
Hata, Yoshiteru, Watanabe, Masamichi, Matsubara, Takashi, Touchi, Akira |
| Zdroj: |
Chemistry Letters; October 1978, Vol. 7 Issue: 10 p1069-1072, 4p |
| Abstrakt: |
We studied the substituent effect on the metabolism of ortho-, meta- and para-alkoxyaniline mustards. Surprisingly, very high yields of N-chloroethylaniline derivatives from the dechloroethylation reaction of para-alkoxyaniline mustards were obtained. N-2-Chloroethylaniline derivatives converted spontaneously into aziridines in microsomal solution.The order of the reaction rate of mustards in microsomal solution had a good parallel relationship with that of the antitumor activity of corresponding aniline mustards. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
