| Abstrakt: |
With respect to “up” amination of the sugar part of nucleosides through an appropriate N-cyclonucleoside, 5′,N-anhydro-2,2′-imino-1-(2′-deoxy-β-D-arabinofuranosyl)uracil proved to be easily hydrolyzed to 1-(2′,5′-N-anhydro-5′-amino-2′,5′-dideoxy-β-D-arabinofuranosyl)uracil (2) in dilute alkaline or acidic medium. 2was characterized as its acetylimino analogue or hydrochloride, and proved to trans form to 5′,N-anhydro-6,2′-imino-1-(2′-deoxy-β-D-arabinofuranosyl)-5,6-dihydrouracil spontaneously. |
