Imidazoles. II. A General Synthesis for 1-Hydroxyimidazoles

Autor: Akagane, Katsuo, Allan, F J, Allan, G G, Friberg, T, Muircheartaigh, S Ó, Thomson, J B
Zdroj: Bulletin of the Chemical Society of Japan; November 1969, Vol. 42 Issue: 11 p3204-3207, 4p
Abstrakt: The reaction of a-dione monoximes with aldehydes and ammonia affords a general and facile synthetic route to 1-hydroxyimidazoles. By selection of the starting materials substituents can be readily introduced into the 2,4 and/or 5 positions of the imidazole ring which is formed viathe intermediacy of a gem-aminoalcohol. The reactions of the N-hydroxyl function are discussed.
Databáze: Supplemental Index