| Autor: |
Imoto, Masahiro, Yoshimura, Hiroyuki, Yamamoto, Michiharu, Shimamoto, Tetsuo, Kusumoto, Shoichi, Shiba, Tetsuo |
| Zdroj: |
Bulletin of the Chemical Society of Japan; June 1987, Vol. 60 Issue: 6 p2197-2204, 8p |
| Abstrakt: |
2,2′-N:3,3′-O-Tetrakis[(R)-3-hydroxytetradecanoyl]-β(1-6)-d-glucosamine disaccharide 1,4′-bis(phosphate) and its dephospho derivatives were synthesized. The bisphosphate prepared was shown to be identical with a natural biosynthetic precursor of lipid A which corresponds to the lipophilic part of lipopolysaccharide (LPS) in bacterial cell wall. The synthetic bis- and monophosphates exhibited many of typical endotoxic activities of LPS. Consequently, this work established the chemical structure of the biosynthetic precursor of lipid A and elucidated the fundamental structure required for the expression of these activities. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
