| Autor: |
Kusumoto, Shoichi, Yamamoto, Koji, Imoto, Masahiro, Inage, Masaru, Tsujimoto, Masachika, Kotani, Shozo, Shiba, Tetsuo |
| Zdroj: |
Bulletin of the Chemical Society of Japan; May 1986, Vol. 59 Issue: 5 p1411-1417, 7p |
| Abstrakt: |
Two disaccharide dipeptides, i.e., O-(N-acetyl-β-d-glucosaminyl)-(1→4)-N-acetylmuramyl-l-alanyl-d-isoglutamine (2) and O-(N-acetyl-β-muramyl-l-alanyl-d-isoglutamine)-(1→4)-N-acetyl-d-glucosamine (3), which correspond to partial structures of cell wall peptidoglycan were synthesized via the same glucosamine disaccharide as a common intermediate. Thus, selective introduction of lactic acid moiety on either one of the sugar moieties of the intermediate gave two disaccharides respectively which contain muramic acid on either reducing or nonreducing side. Coupling of the peptide moiety followed by deprotection afforded 2and 3. The results of biological tests showed that both 2and 3have the same magnitude of immunostimulating activities as those of N-acetylmuramyl-l-alanyl-d-isoglutamine which is the minimum structure required for expression of the activities. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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