| Autor: |
Furusaki, Akio, Hashiba, Nobuhiro, Matsumoto, Takeshi, Hirano, Atsushi, Iwai, Yuzuru, \={O}mura, Satoshi |
| Zdroj: |
Bulletin of the Chemical Society of Japan; December 1982, Vol. 55 Issue: 12 p3681-3685, 5p |
| Abstrakt: |
The molecular sturcture of staurosporine, an alkaloid from a Streptomycesstrain, has been determined by means of an X-ray crystallographic analysis of its methanol solvate (C28H26N4O3·CH3OH). The crystals are monoclinic, with four formula units in a unit cell with dimensions of a=23.487(6), b=7.636(3), c=15.638(4) Å, and ß=116.71(5)°; the space group is C2. 2532 unique intensity data were collected on a four-circle diffractometer with LiF-monochromated Cu Ka radiation. The structure was solved by the Monte Carlo direct method, using the 20 strongest reflections as the starting set; the 72nd random phase set led to the correct solution. The Rvalue reached 0.047 by block-diagonal least-squares refinements. Staurosporine has been found to contain a unique dimeric indole structure. Because of the steric hindrance, the indolo[2,3-a]carbazole aromatic system in the molecule is slightly bent; the two terminal benzene rings make an angle of 7.5° with each other. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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