Preparations of Na-Fmoc-O-[(Benzyloxy)hydroxyphosphinyl] ß-Hydroxy a-Amino Acid Derivatives

Autor: Wakamiya, Tateaki, Nishida, Takatoshi, Togashi, Ryusaku, Saruta, Kunio, Yasuoka, Jun-ichi, Kusumoto, Shoichi
Zdroj: Bulletin of the Chemical Society of Japan; February 1996, Vol. 69 Issue: 2 p465-468, 4p
Abstrakt: Na-Fmoc-O-[(benzyloxy)hydroxyphosphinyl]serine and Na-Fmoc-O-[(benzyloxy)hydroxyphosphinyl]threonine were prepared in order to be utilized for the synthesis of phosphoserine- or phosphothreonine-containing peptides based on the Fmoc-mode pre-phosphorylation strategy. These derivatives were obtained as crystalline compounds, which are favorable for use as building blocks for an automated peptide synthesis by a solid-phase method.
Databáze: Supplemental Index