| Autor: |
Luan, Wei, Zheng, Meiyun, Yang, Youlin, Chen, Yi, Zhang, Xiahui, Zhu, Lingping, Lin, Chenxiao |
| Zdroj: |
Gold Bulletin; 20240101, Issue: Preprints p1-12, 12p |
| Abstrakt: |
Since their discovery, graphene nanocomposites have attracted much attention for their potential use in many biological applications. Herein, we examined the highly reduced graphene oxide (HRGO) and gold nanomaterial (AuNM)-based (HRGO/Au@AP) nanocomposite for ovarian cancer and apoptosis-inducing abilities, the nanomaterials’ anticancer activities against human ovarian cancer cell lines (SKOV3 and A2780). HRGO was functionalized with the 1-aminopyridine (AP) as a potential stabilizing agent to improve the sample’s solubility and bioavailability. The surface morphology and structure of the nanocomposites were examined by high-resolution transmission electron microscopy. The results of an anticancer study comparing HRGO, HRGO/Au, and HRGO/Au@AP nanocomposites showed a greater capacity to induce apoptosis, the apoptosis assays (AO-EB, DAPI, and Annexin V-FITC/PI staining) and reactive oxygen species (ROS) measurements on SKOV3 and A2780 cells. This data suggests that HRGO/Au@AP promotes potent apoptosis in human ovarian cancer cells. |
| Databáze: |
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