| Autor: |
Sadeer, Nabeelah Bibi, Haddad, Juliano G., Ezzat, Mohammed Oday, Desprès, Philippe, Abdallah, Hassan H., Zengin, Gokhan, Alshamrani, Ibtesam Mohammad, Barnawi, Jameel, Khalid, Asaad, Abdalla, Ashraf N., Le Van, Bao, El Kalamouni, Chaker, Mahomoodally, Mohamad Fawzi |
| Zdroj: |
Journal of Biomolecular Structure and Dynamics; December 2023, Vol. 41 Issue: 22 p12599-12609, 11p |
| Abstrakt: |
AbstractThe recent appearance of Zika virus (ZIKV) in Brazil should serve as a wake-up call to international authorities, as it poses a threat to global public health. In the present study, we investigated whether a mangrove plant, Rhizophora mucronataLam. (R. mucronata) collected in Mauritius, possesses anti-ZIKV activity at the non-cytotoxic doses. ZIKVMC-MR766NIID (ZIKVGFP) was used for assessing anti ZIKV activity. In silico docking (Autodock 4) and molecular simulation were performed on collected data. Using a recombinant ZIKV expressing reporter green fluorescent protein(GFP) protein, we discovered that fruit and root methanolic, decocted fruit and root extracts were effective inhibitors of ZIKV infection in human epithelial A549 cells at negligible cytotoxicity. The mechanisms by which such extracts prevented ZIKV infection are linked to the inability of the virus to attach to the host cell surface. The outcomes of this study were supported by the docking calculations in which some of the dominant compounds have shown high binding affinity against ZIKV. The scientific data gathered in this study might pave the way for the future development of possible R. mucronatainhibitors to combat ZIKV.fCommunicated by Ramaswamy H. Sarma |
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