| Autor: |
Sarojini, Sharath Shankar, Naik, Meghna U, Kostyak, John C, Naik, Ulhas P. |
| Zdroj: |
Blood; November 2023, Vol. 142 Issue: 1, Number 1 Supplement 1 p2574-2574, 1p |
| Abstrakt: |
Introduction: Sepsis is the body's extreme response to an infection which leads to multiple organ dysfunction and mortality. Males are more susceptible to sepsis than females. It is believed that sex hormones may be responsible for this difference. Recent studies highlight the role of platelets in sepsis. Thrombocytopenia and thrombosis are the major events that occur during sepsis. We have shown that JAM-A, a cell adhesion molecule belonging to Ig superfamily is expressed in platelets and regulates agonist-induced platelet activation by suppressing α IIbβ 3activation in mice. JAM-A is also expressed on leucocytes and endothelial cells, where it regulates leukocyte extravasation and vascular permeability. However, the role of JAM-A in sepsis is poorly understood. |
| Databáze: |
Supplemental Index |
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