O-GlcNAc regulates YTHDF1 and YTHDF3 activity

Autor: Burns, Mary W. N., Kohler, Jennifer J.
Zdroj: Nature Cell Biology; November 2023, Vol. 25 Issue: 11 p1570-1572, 3p
Abstrakt: YTHDF family members are ‘readers’ of a common mRNA modification, but their effects on mRNA translation and stability have been disputed. A new study shows that YTHDF1 and YTHDF3 are post-translationally regulated through O-GlcNAcylation, unifying disparate results and pointing to environmental cues that could modulate YTHDF function.
Databáze: Supplemental Index