Theta Burst Stimulation of the Human Motor Cortex Modulates Secondary Hyperalgesia to Punctate Mechanical Stimuli

Autor: Hodkinson, Duncan J., Drabek, Marianne M., Jung, JeYoung, Lankappa, Sudheer T., Auer, Dorothee P.
Zdroj: Neuromodulation: Technology at the Neural Interface; 20230101, Issue: Preprints
Abstrakt: Many chronic pain conditions show evidence of dysregulated synaptic plasticity, including the development and maintenance of central sensitization. This provides a strong rationale for neuromodulation therapies for the relief of chronic pain. However, variability in responses and low fidelity across studies remain an issue for both clinical trials and pain management, indicating insufficient mechanistic understanding of effective treatment protocols.
Databáze: Supplemental Index