| Autor: |
Matsumoto, Yoshihiro, Sato, Hideki, Miyai, Hironobu, Sato, Motoyoshi, Morita, Hiroyuki, Amano, Izumi |
| Zdroj: |
Blood Purification; December 2003, Vol. 21 Issue: 4-5 p287-293, 7p |
| Abstrakt: |
Background:Conventional peritoneal dialysates are potentially bioincompatible and seem to be a causative factor for peritoneal sclerosis. Recent studies demonstrated that a new type of dialysate has a positive long-term clinical effect on dialysis patients. Methods:In this study, to elucidate the short-term biological effects of a newly developed dialysate of higher pH on the peritoneal membrane, we assessed macrophage proportions and several markers (inflammatory cytokines, cancer antigen 125 (CA125) and albumin) in spent dialysates before and 2 weeks after the change to the new fluid from a conventional fluid. Results:We found that the use of the new dialysate decreased intraperitoneal levels of inflammatory cytokines, CA125 and albumin associated with the decrease of macrophage populations in dialysis effluents. Conclusion:These observations suggest that a new and less acidic fluid reduces pro-inflammatory potential in the peritoneum, and thus affords better preservation of peritoneal membrane integrity in uremic patients on peritoneal dialysis. |
| Databáze: |
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