| Abstrakt: |
Three different metal oxides, viz.,copper oxide (CuO), nickel oxide (NiO) and zinc oxide (ZnO) nanoparticles, were green synthesized using Wattakaka volubilis(WV) leaf extract via a simple cost-effective co-precipitation method. The X-ray diffraction (XRD) and scanning electron microscope (SEM) studies were carried out for material identification and surface morphology of the prepared materials. The gas chromatography–mass spectroscopy (GC-MS) and Fourier transform infrared (FTIR) studies confirmed the presence of the phytochemicals in the extract and their influence on the synthesized nanoscale systems. All the three synthesized materials exhibit good biomedical activities tested in this study, viz.,antioxidant, antidiabetic and antibacterial. Three assays, viz.,DPPH (2,2-diphenylpicrylhydrazyl), ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and SO (Superoxide), antidiabetic activity by α-glucosidase inhibition assay and antibacterial activity by disc diffusion method were examined for all the three prepared samples. The IC50value of CuO is 106.27 ± 1.53 μg/mL which is not only better than those of the synthesized NiO (IC50of 124.78 ± 1.97) and ZnO (138.13 ± 1.54 μg/mL), but also than the control acarbose which showed an IC50of 116.31 ± 1.66 μg/mL. Among the three nanoparticles, CuO exhibits its predominance in all the three biomedical activities owing to its enhanced characteristics like smaller grain and crystallite size and effective and large number of interactive sites. The study revealed that the Wattakaka volubilispowered CuO, NiO and ZnO nanomaterials are promising for biomedical applications like antioxidant, antidiabetic, antibacterial and antifungal activities. |
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