| Autor: |
Gu, Yang, Lu, Xueyao, Liu, Tongkang, Song, Yanjin, Sang, Ellie, Ding, Shuran, Liu, Long, Xue, Feng, Xu, Peng |
| Zdroj: |
Food Bioengineering; September 2023, Vol. 2 Issue: 3 p187-199, 13p |
| Abstrakt: |
The oleaginous yeast, Yarrowia lipolytica, has garnered much attention and is gaining recognition as a potential industrial platform for nutraceutical production. The superior properties of Y. lipolyticainclude its transparent inherited background, broad substrate spectrum, and superior environmental tolerance. Specifically, advances in genetic tools and engineering strategies have further widened its applications in metabolic engineering and biomanufacturing. In this review, we summarized developments in synthetic biology and engineering strategies for constructing Y. lipolyticato produce nutraceuticals. We also proposed perspectives on the limitations and challenges in developing microbial Y. lipolyticafactories. Yarrowia lipolyticapossesses a transparent inherited background, relatively mature molecular manipulations, and controllable metabolic regulations, making it one of the most popular and extensively researched nonconventional yeasts. Its broad substrate spectrum and superior environmental tolerance make it attractive to develop as a microbial cell factory for numerous biochemicals and nutraceuticals production. Moreover, the latest development of genetic tools and engineering strategies also widens its applications in metabolic engineering. |
| Databáze: |
Supplemental Index |
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