CBFA2T3::GLIS2 Pediatric Acute Megakaryoblastic Leukemia is Sensitive to BCL-XLInhibition by Navitoclax and DT2216

Autor: Gress, Verena, Roussy, Mathieu, Boulianne, Luc, Bilodeau, Mélanie, Cardin, Sophie, El-Hachem, Nehme, Lisi, Véronique, Khakipoor, Banafsheh, Rouette, Alexandre, Farah, Azer, Théret, Louis, Aubert, Léo, Fatima, Furat, Audemard, Éric, Thibault, Pierre, Bonneil, Éric, Chagraoui, Jalila, Laramée, Louise, Gendron, Patrick, Jouan, Loubna, Jammali, Safa, Paré, Bastien, Simpson, Shawn M., Tran, Thai Hoa, Duval, Michel, Teira, Pierre, Bittencourt, Henrique, Santiago, Raoul, Barabé, Frédéric, Sauvageau, Guy, Smith, Martin A., Hébert, Josée, Roux, Philippe P., Gruber, Tanja A., Lavallée, Vincent-Philippe, Wilhelm, Brian T., Cellot, Sonia
Zdroj: Blood Advances; 20230101, Issue: Preprints
Abstrakt: 1.Cord blood–derived CBFA2T3::GLIS2 high-fidelity AMKL models contribute to capture the cellular and molecular heterogeneity of the disease2.BCL-XLinhibition is revealed as a therapeutic vulnerability in CG2 and NUP98r AMKL
Databáze: Supplemental Index