| Autor: |
de Ruiter Swain, Jed, Michalopoulou, Evdokia, Noch, Evan K., Lukey, Michael J., Van Aelst, Linda |
| Zdroj: |
Genes & Development; 2023, Vol. 37 p681-702, 22p |
| Abstrakt: |
In this review, de Ruiter Swain et al. discuss the mechanisms of intercellular metabolite exchange underpinning glucose, fatty acid, and amino acid homeostasis in the healthy brain. They further illustrate how these metabolic processes are exploited by glioblastoma to provide essential nutrients for tumor growth and modulation of the tumor microenvironment, highlighting that targeting metabolic dependencies could be a potential therapeutic avenue against this aggressive brain cancer. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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