| Autor: |
Bardoux, Pascale, Bichet, Daniel Georges, Martin, Hélène, Gallois, Yves, Marre, Michel, Arthus, Marie-Françoise, Lonergan, Michèle, Ruel, Nicole, Bouby, Nadine, Bankir, Lise |
| Zdroj: |
Nephrology Dialysis Transplantation; March 2003, Vol. 18 Issue: 3 p497-506, 10p |
| Abstrakt: |
An increase in urinary albumin excretion (UAE) represents an early predictor of glomerular damage in diabetes mellitus (DM) and a risk factor for cardiovascular complications in hypertension. Vasopressin is elevated in DM and in some forms of hypertension. Previous studies in rats suggested that this hormone could play a role in the albuminuria observed in chronic renal failure or diabetic nephropathy, but no information is available concerning the mechanism of these effects and the possible influence of vasopressin on UAE in the healthy kidney. The present study was thus designed to evaluate whether vasopressin influences UAE in normal rats and humans, whether this effect is V(2)-receptor-dependent, and whether it is mediated by the renin-angiotensin system. |
| Databáze: |
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