Chemical-genetics refines transcription factor regulatory circuits

Autor: Layden, Hillary M., Johnson, Anna E., Hiebert, Scott W.
Zdroj: Trends in Cancer; 20230101, Issue: Preprints
Abstrakt: Degron tags enable temporal analysis of transcription perturbation and identification of direct transcriptional targets.Transcription factors control small networks of genes despite binding to thousands of sites.Inducible degradation provides the specificity and temporal control to define the contributions of individual subunits to the function of multiprotein complexes.
Databáze: Supplemental Index