| Autor: |
Sato, Seidai, Koyama, Kazuya, Ogawa, Hirohisa, Murakami, Kojin, Imakura, Takeshi, Yamashita, Yuya, Kagawa, Kozo, Kawano, Hiroshi, Hara, Eiji, Nishioka, Yasuhiko |
| Zdroj: |
Respiratory Investigation; November 2023, Vol. 61 Issue: 6 p781-792, 12p |
| Abstrakt: |
Recent studies suggest that cellular senescence is related to the pathogenesis of idiopathic pulmonary fibrosis. However, cellular senescence has yet to be targeted therapeutically in clinical practice. ARV825, a recently developed BRD4 degrader, has been reported as a novel senolytic drug. Conversely, it has also been reported that BRD4 regulates the pro-fibrotic gene expression of fibroblasts. Therefore, this study focuses on the senolytic and anti-fibrotic effects of ARV825 and evaluated these effects on lung fibrosis. |
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