| Abstrakt: |
Background: The emergence of healthcare-associated infections (HAIs) or superinfections in COVID-19 patients has resulted in poor prognosis and increased mortality. Methods: In a cross-sectional study, 101 respiratory samples were collected from ICU-admitted COVID-19 patients. The HAI rate, demographics, and antibiotic resistance were assessed. Results: The HAI rate was 83.16% (76.62% bacterial and 6.54% fungal). The prevalence of 3 major HAI-causing organisms included Klebsiella pneumoniae(41.5%), Acinetobacter baumannii(20.8%), and Staphylococcus aureus(4.9%). Mortality and intubation ventilation proportions of 90% (p= 0.027) and 92.2% (p= 0.02) were significant among patients with superinfection, respectively. Multiple logistic regression analysis showed SpO2pressure (odds ratio 0.842; 95% CI 0.750–0.945; p= 0.004) as a predictive factor in the association between antibiotic usage and mortality. More than 50% of patients received carbapenems. The resistance rates to at least one antibiotic of third-generation cephalosporins, aminoglycosides, quinolones/fluoroquinolones, tetracyclines, and β-lactam inhibitors were 95.2%, 95.2%, 90%, 57.1%, and 100% among A. baumanniiisolates and 71.4%, 55%, 69%, 61.9%, and 59.5% among K. pneumoniaeisolates, respectively. A proportion of 60% was recorded for methicillin-resistant S. aureusisolates. Conclusion: As a result, antibiotic treatment should be administered following the microbial resistance profile. Contact isolation and infection control measures should be implemented as needed. |
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