| Autor: |
Mills, Susan, Yang, Bo, Smith, Graeme J., Stanton, Catherine, Ross, R. Paul |
| Zdroj: |
Gut Microbes; December 2023, Vol. 15 Issue: 1 |
| Abstrakt: |
ABSTRACTThe significance of Bifidobacteriumto human health can be appreciated from its early colonization of the neonatal gut, where Bifidobacterium longumrepresents the most abundant species. While its relative abundance declines with age, it is further reduced in several diseases. Research into the beneficial properties of B. longumhas unveiled a range of mechanisms, including the production of bioactive molecules, such as short-chain fatty acids, polysaccharides, and serine protease inhibitors. From its intestinal niche, B. longumcan have far-reaching effects in the body influencing immune responses in the lungs and even skin, as well as influencing brain activity. In this review, we present the biological and clinical impacts of this species on a range of human conditions beginning in neonatal life and beyond. The available scientific evidence reveals a strong rationale for continued research and further clinical trials that investigate the ability of B. longumto treat or prevent a range of diseases across the human lifespan. |
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