| Abstrakt: |
Phytochemical study of Knema pachycarpaleaves led to the isolation of ten compounds. Their chemical structures were determined as (7”R, 8”R)‐hydnocarpin D (1), (7”R, 8”R)‐hydnocarpin (2), sinaicitin (3), (‐)‐globulol (4), β‐caryolanol (5), phytol (6), biochanin A (7), chrysoeriol (8), tanoside II (9) and astragalin (10) using NMR and MS spectral data. Among the isolates, (7”R, 8”R)‐hydnocarpin (2) showed good cytotoxic activity against KB, HepG‐2, Lu and MCF‐7 cancer cell lines with IC50values from 13.99±0.62 μg/mL to 30.65±1.44 μg/mL. Compound 4showed selective cytotoxicity against LU cancer cell line and significant acetylcholinesterase (AChE) inhibition with IC50values of 12.31±0.51 μg/mL and 5.12±0.22 μg/mL, respectively. |
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