| Abstrakt: |
Despite the existence of traditional and modern investigational products, all facets/types of wounds are not adequately addressed by current wound care. It has been proven that a number of wound healing herbs target various biological pathways and important events in the mammalian wound healing cascade. This study aimed to develop the nanosized ethanol extract of Acalypha indica(Ai) – a wound healing herb of both traditional medicine and evidence-based research repute into a wound dressing product. Blended into a polymer matrix of guar gum, polyvinyl alcohol, and chitosan, it was solvent casted as a thin film (PBTFAi) and characterized for ambient wound dressing material parameters using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric–differential scanning calorimetry (TG-DSC), swelling index, protein adsorption, tensile strength, antimicrobial efficacy, human dermal fibroblast (HDF) proliferation, and calcein acetoxymethyl ester (calcein AM) staining. The FTIR spectroscopic frequencies of PBTFAi relative to the plain polymer blend thin film (PBTF) revealed a significant polymer/Ai blending. Its thermal stability, morphological characteristics, exudate absorbability, tensile strength, anti-bacterial activity, cytocompatibility, and HDF proliferation (95%) compared to PBTF (79%) have all established the parameters for an effective wound dressing, demonstrating its potential to be developed as an ethical plant bioactive-based wound dressing that both protects and heals. |
Full text from SpringerLink