Association Between Prenatal Per- and Polyfluoroalkyl Substance Exposure and Maternal Serum Total Bile Acid Levels During Pregnancy: Effect Modification by Infant Sex and Maternal Prepregnancy BMI

Autor: Liao, Qian, Huang, Huishen, Tang, Peng, Liang, Jun, Chen, Jiehua, Lei, Lei, Song, Yanye, Pan, Dongxiang, Lin, Mengrui, Lv, Fangfang, Liang, Xue, Zeng, Xiaoyun, Liu, Shun, Huang, Dongping, Qiu, Xiaoqiang
Zdroj: Exposure and Health; June 2024, Vol. 16 Issue: 3 p727-744, 18p
Abstrakt: Bile acids play an important role in metabolic modulation and elevated serum total bile acid (sTBA) levels during pregnancy are linked to adverse perinatal outcomes. Previous studies have reported that per- and polyfluoroalkyl substances (PFAS) have a strong impact on bile acid synthesis in vitro. However, epidemiological evidence regarding PFAS exposure and maternal sTBA levels is limited. Our aim in this study was to determine the effects of PFAS exposure on maternal sTBA levels, with exploration of the interaction effect of infant sex and prepregnancy BMI on the association between PFAS exposure and maternal sTBA levels. We included 975 pregnant women from the Guangxi Zhuang Birth Cohort. Nine PFAS were quantified by ultraperformance liquid chromatography‒mass spectrometry. sTBA data were obtained from medical records. In single-exposure analysis, exposure to perfluoroundecanoic acid (PFUnA) was positively associated with maternal sTBA levels, and this finding was more pronounced in pregnant women with female infants and a prepregnancy BMI ≥ 24 kg/m2. In multiple-exposure analysis, there was no significant association of mixed PFAS exposure with maternal sTBA levels. Infant sex might modify this effect. There was a decreasing trend of mixed PFAS exposure with sTBA levels in pregnant women with male infants, and perfluorooctane sulfonate (PFOS) was the main contributor. In contrast, there was an increasing trend of mixed PFAS exposure with sTBA levels in pregnant women with female infants, and PFUnA was the main contributor. In summary, prenatal exposure to PFAS are associated with maternal sTBA levels during pregnancy, and the association may exhibit heterogeneity according to infant sex and prepregnancy BMI.
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